ABSTRACT
Background Several studies are ongoing to obtain more information about post-COVID-19 (corona virus disease-19) pulmonary fibrosis. Old-aged patients are more likely to evolve lung fibrosis in COVID-19. Another risk factor is the degree of disease severity, including comorbidities, such as hypertension, diabetes, as well as lab findings, for example, lymphopenia and leukocytosis. Aims of work To assess the prevalence of post-COVID-19 pulmonary fibrosis and reveal some of its predictors. Results The study included 50 patients in the outpatient clinics of Chest and EL-Helal Hospitals with a mean age of 49.6 +/- 17.7 years. It included 32 (64%) males and 18 (36%) females. Pulmonary fibrosis was detected in 34 (68%) patients. Pulmonary fibrosis was bilateral in 24 patients and unilateral in 10 patients. Leucopenia, elevated serum ferritin, elevated D-dimer, and elevated C-reactive protein (CRP) were associated with pulmonary fibrosis (P value 0.001). Conclusion Pulmonary fibrosis is recognized as a complication between survivors. Immune response due to lung injury by viral infection, and trials to repair are keys to the procedure of fibro genesis. Predictors of lung fibrosis involve increased lab parameters such as serum ferritin, C-reactive protein, and D-dimer. Copyright © 2022 The Egyptian Journal of Chest Diseases and Tuberculosis.
ABSTRACT
Background Determination of predictors of coronavirus disease 2019 (COVID-19) severe infection allows early intervention and appropriate treatment of patients at risk, so that we can improve outcome and allow better selection of patients who need hospitalization. Our aim is detection of factors linked to higher rates of complications and death in COVID-19 hospitalized patients. Results The study included 151 patients who were divided into mild, moderate, and severe groups;patients with age more than or equal to 60 were more in the severe category (P=0.001). The severe category had considerably more comorbidities (P=0.001). Patients with more than or equal to two comorbidities were more likely to be in the severe category (P=0.006). Obese patients with BMI more than 30 were substantially more likely to be in the severe category (P=0.004). Cough, fever, dyspnea, and vomiting were the most common presentations. Complications of COVID-19 infection were more likely to be detected in the severe category (P=0.001). In the severe category, lymphopenia, raised neutrophil-to-lymphocyte ratio, C-reactive protein, ferritin, lactate dehydrogenase, and D-dimer were all considerably higher. O 2 saturation on admission was significantly lower in the severe group with mean (SD) of 81.23 +/- 9.22. Duration of admission was significantly longer in the severe group with a range of 9 (3-27) days. Mortality rate in our study was 7.9% (12 cases);all dead cases were included within the severe group. Conclusion Physicians should consider patients diagnosed as COVID-19 with high ferritin, elevated neutrophil-to-lymphocyte ratio, lymphopenia, obesity, and high D-dimer as risky for severe infection and need hospitalization with intensive care and proper management to decrease complications, mortality, and for proper triage of COVID-19 patients in hospitals. Copyright © 2022 Indian Journal of Anaesthesia Published by Wolters Kluwer - Medknow.